EDUCATIONPh.D., Louisiana State University School of Veterinary Medicine, Baton Rouge, LA, 2011, Veterinary Medical Sciences
M.S., Louisiana State University, Baton Rouge, LA, 2006, Human Nutrition
B.S., Louisiana State University, Baton Rouge, LA, 2001, Dietetics
RESEARCH INTERESTSDr. Elks has a general interest in the effects of the extracellular matrix on tissue function in obesity and diabetes. More specifically, she is interested in understanding how the adipose tissue extracellular matrix affects adipocyte function and adipose tissue homeostasis. Her current research is focused on: 1) how cytokines affect the function and composition of the adipose tissue extracellular matrix, and 2) how alterations in the adipose tissue extracellular matrix affect adipocyte function and insulin sensitivity.
SELECTED PUBLICATIONSBurke SJ, Karlstad MD, Regal KM, Sparer TE, Lu D, Elks CM, Grant RW, Stephens JM, Burk DH, Collier JJ. (2015) CCL20 is elevated during obesity and differentially regulated by NF-?B subunits in pancreatic ß-cells. Biochim Biophys Acta. 1849(6):637-652.
Elks CM and Stephens JM. (2015) Oncostatin M modulation of lipid storage. Biology. 4(1):151-160.
Elks CM, Terrebonne JD, Ingram DK, Stephens JM. (2015) Blueberries improve glucose tolerance and lipid handling without altering body composition in obese postmenopausal mice. Obesity. 23(3):573-80.
Ruggiero C, Elks CM, Kruger C, Cleland E, Addison K, Noland RC, Stadler K. (2014) Albumin-bound fatty acids but not albumin itself alter redox balance in tubular epithelial cells and induce a peroxide-mediated redox-sensitive apoptosis. Am J Physiol Renal Physiol. 306(8):F896-906.
Zhao P, Elks CM, Stephens JM. (2014) The induction of lipocalin-2 protein expression in vivo and in vitro. J Biol Chem. 28;289(9):5960-9.
Sanchez-Infantes D, White UA, Elks CM, Morrison RF, Gimble JM, Considine RV, Ferrante AW, Ravussin E, Stephens JM. (2014) Oncostatin M is produced in adipose tissue and is regulated in conditions of obesity and type 2 diabetes. J Clin Endocrinol Metab. 99(2):E217-25.
Mariappan M, Elks CM, Haque M, Francis J. (2012) Interaction of TNF with angiotensin II contributes to mitochondrial oxidative stress and cardiac damage in rats. PLoS One. 7(10):e46568.
Agarwal D*, Elks CM*, (*equal contribution), Reed SD, Mariappan N, Majid DS, Francis J. (2012) Chronic Exercise Preserves Renal Structure and Hemodynamics in Spontaneously Hypertensive Rats. Antioxid Redox Signal. 16(2): 139-152.
Elks CM, Reed SD, Mariappan N, Shukitt-Hale B, Joseph JA, Ingram DK, Francis J. (2011) A Blueberry-Enriched Diet Attenuates Nephropathy in a Rat Model of Hypertension via Reduction in Oxidative Stress. PLoS One. 6(9):e24028.
Cardinale JP, Sriramula S, Pariaut R, Guggilam A, Mariappan N, Elks CM, Francis J. (2010) HDAC inhibition attenuates inflammatory, hypertrophic, and hypertensive responses in spontaneously hypertensive rats. Hypertension. 56(3):437-44.
Elks CM and Francis J. (2010) Central adiposity, systemic inflammation, and metabolic syndrome. Curr Hypertens Rep. 12(2):99-104.
Mariappan N, Elks CM, Sriramula S, Guggilam A, Liu Z, Borkhsenious O, Francis J. (2010) NF-?B- induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes. Cardiovasc Res. 85(3):473-83.
Ebenezer PJ, Mariappan N, Elks C, Haque M, Soltani Z, Reisin E, Francis J. (2009) Effects of pyrrolidine dithiocarbamate on high-fat diet-induced metabolic and renal alterations in rats. Life Sci. 85(9-10):357-64.
Ebenezer PJ, Mariappan N, Elks CM, Haque M and Francis J. (2009) Diet-induced Renal Changes in Zucker Rats Are Ameliorated by the Superoxide Dismutase Mimetic TEMPOL. Obesity 17(11):1994-2002.
Elks CM, Mariappan N, Haque M, Guggilam A, Majid DS, Francis J. (2009) Chronic NF-kB blockade reduces cytosolic and mitochondrial oxidative stress and attenuates renal injury and hypertension in SHR. Am J Physiol Renal Physiol. 296(2):F298-305.
Mariappan N, Elks CM, Fink B, Francis J. (2009) TNF-induced mitochondrial damage: a link between mitochondrial complex I activity and left ventricular dysfunction. Free Radic Biol Med. 46(4):462-70.